Antiviral Drugs Targeting Host Proteins an Efficient Strategy

CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy

Currently, a new gene editing tool-the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system-is becoming a promising approach for genetic manipulation at the genomic level. This simple method, originating from the adaptive immune defense system in prokaryotes, has been developed and applied to antiviral research in humans. Based on the characteristics of vir...

Targeting cell entry of enveloped viruses as an antiviral strategy.

The entry of enveloped viruses into their host cells involves several successive steps, each one being amenable to therapeutic intervention. Entry inhibitors act by targeting viral and/or cellular components, through either the inhibition of protein-protein interactions within the viral envelope proteins or between viral proteins and host cell receptors, or through the inhibition of protein-lip...

Targeting Norovirus: Strategies for the Discovery of New Antiviral Drugs

Advances in the Host Antiviral CCCH-Zinc Finger Proteins

Zinc-finger proteins (ZFPs) are the largest transcription factor family in human genome. They have recently become an area of intense study because of their broad range of biological functions, including development, differentiation, metabolism, autophagy, cancer progression and more recently because they are attractive targets for antiviral therapy [1]. The zinc fingers was first recognized as...

Towards drugs targeting multiple proteins in a systems biology approach.

Protein-protein interactions are increasingly becoming drug targets. This is understandable, since they are crucial at all levels of cellular expression and growth. In practice, targeting specific disease-related interactions has proven difficult, with success varying with specific complexes. Here, we take a Systems Biology approach to targeting protein-protein interactions. Below, we first bri...